Many were associated with both basal and ERBB2 sub-types such as WNT5B and others specifically in basal cancers such as LRP5/6 and sFRP1. Lower levels of sFRP1 or LRP6 predict an early recurrence in ER+ve breast cancer whilst higher levels of WNT5B expression predict early recurrence. The gene discussed is LRP6; the disease is breast carcinoma.