NOTCH4 and asthma: Genome-wide association (GWA) studies on asthma have suggested that several polymorphisms in several genes, including ORMDL3-GSDMB, DENND1B, HLA-DP, SLC30A8, IL1RL1-IL18R1, IL33, SMAD3, TSLP, and NOTCH4[32]–[35] are associated with asthma.