Some of these genes have been identified in association with neurological disorders and may therefore have roles in the nervous system lesion-induced EV71 infection, such as SGK, CYFIP1, NDEL1, KIAA1212, BCAN, SF3B3, SMC1A, and TCN1. Other genes, such as AMOTL2, PCYT2, and SMARCC1, were reported to relate to immune and inflammatory responses. The gene discussed is SMC1A; the disease is nervous system disorder.