The haplotype analysis and the expression profile for the studied significant SNPs in the PARK2 gene regulatory region confirmed that the risk allele for the significantly associated SNPs were responsible for an increased risk towards leprosy and the same risk SNP allele disrupted the transcription factor binding site in a bioinformatics analysis, confirmed further by a reduction in expression in an in-vitro reporter (luciferase) expression analysis. This evidence concerns the gene PRKN and leprosy.