Apart from those in FTO, several of the identified SNPs are located in or near genes clearly related to appetite regulation (Willer et al. 2009), and recently, five of the novel obesity loci (SH2B1, KCTD15, MTCH2, NEGR1 and BDNF) were indicated to be associated with dietary macronutrient intake levels (Bauer et al. 2009). This evidence concerns the gene SH2B1 and obesity due to melanocortin 4 receptor deficiency.