Two isoflavones, genistein and biochanin A, decreased the cell growth of OSCC cell lines with an IC50 of 50 μM and inhibited phosphorylation of ERK (extracellular signal-regulated kinase) and Akt, a mitogen-activated protein kinase (MAPK) and a serine/threonine protein kinase, respectively, involved in oral cancer proliferation [17]. This evidence concerns the gene AKT1 and lip and oral cavity carcinoma.