RFC1 and myelodysplastic syndrome: Since several additional papers have been published in recent years, including studies in Asian [21,23], European [27], and Brazilian populations [24,26,29], we performed the present meta-analysis of the genetic association studies that investigated the RFC-1 80A>G polymorphism as a maternal risk factor for having a birth with DS, including nine independent case-control studies (Table 1) for a total of 930 MDS and 1240 control mothers.