RFC1 and myelodysplastic syndrome: A meta-analysis [15] of four genetic association studies [19,20,22,25], for a total of 354 MDS and 644 control mothers, was performed in 2009 to address the role of the RFC-1 80A>G polymorphism as a maternal risk factor for the birth of a child with DS, and showed a trend toward an association under the dominant model (GG + AG vs. AA) with an odds ratio (OR) of 1.32 (95% CI = 0.95–1.82) [15], suggesting the need of additional studies to further address the contribution of this polymorphism to the maternal risk of having a DS child.