RPE65 and Leber congenital amaurosis: Numerous gene mutations have been reported to cause LCA in humans including RPE65, LRAT, CRX (Homeodomain transcription factor), CRB1 (Crumbs like protein 1), TULP1 (Tubby-like protein), AIPL1 (aryl hydrocarbon interacting protein), and various other genes [84].