Rod opsin on the other hand is observed to traffic normally in the absence of 11-cis-retinal, both in Lrat and Rpe65 knockout mice, suggesting that rod pigment does not necessarily need its chromophore for proper photoreceptor localization [74], whereas 11-cis-retinal deficiency can induce abnormality of length and morphological structures of rod outer segments in LCA mouse models [74,78]. The gene discussed is RPE65; the disease is Leber congenital amaurosis.