In conclusion, the EGF-NIR probe could be utilized for visualization of EGFR in the NCI-60 panel of tumor derived cell lines, and to complement other means of detection of adenomatous polyps and EGFR-expressing tumors in a clinical settings, either ex vivo or alternatively in vivo, with the aid of a suitable NIR endoscope. The gene discussed is EGF; the disease is neoplasm.