CDH1 and neoplasm: Further analysis of TMPRSS4-mediated signaling in colon cancer cells suggested that multiple downstream signaling pathways are activated including focal adhesion kinase (FAK) and extracellular signal regulated kinase (ERK) resulting in the downregulation of E-cadherin and induced expression of integrin α5, a critical molecule implicated in tumor cell invasion, migration and tumor progression [12,13].