MAPT and Alzheimer disease: There are 79 putative serine or threonine phosphorylation sites in the longest human brain tau isoform, and more than 30 phosphorylation sites have been identified in AD brain, including Thr39, Ser46, Thr50, Thr69, Thr153, Thr175, Thr181, Ser184, Ser185, Ser195, Ser198, Ser199, Ser202, Thr205, Ser208, Ser210, Thr212, Ser214, Thr217, Thr231, Ser235, Ser237, Ser238, Ser245, Ser258, Ser262, Ser285, Ser293, Ser305, Ser320, Ser324, Ser352, Ser356, Thr377, Ser396, Ser400, Thr403, Ser404, Ser409, Ser412, Ser413, Ser416 and Ser422 [34–39].