The fluid accumulation may occur due to a relative lack of lymphatic drainage in the large benign tumors leading to pressure lead exudation of interstitial fluid [6] or may be related to the production of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF) by the tumor leading to increased local capillary permeability [7]. The gene discussed is VEGFA; the disease is benign neoplasm.