IL4 and asthma: Our data demonstrated that maternal exposure to MCP230 induced oxidative stress in the dams and enhanced allergen-induced asthma pathophysiology in the offspring, including increased severity of pulmonary eosinophilic inflammation, AHR in response to methacholine, and Th2 cell percentages and cytokine levels in BALF (e.g. IL-4 and IL-5).