APBB1IP encodes the Rap1–GTP-interacting adaptor molecule (RIAM) and is involved in mediating changes in the actin cytoskeleton after integrin-mediated adhesion, and is already a candidate gene for late-onset AD based on linkage analyses at chromosome 10 (Hernandez-Varas et al., 2011; Lafuente et al., 2004; Morgan et al., 2007). Here, APBB1IP is linked to Alzheimer disease.