Finally, we demonstrate significant enrichment of candidate genes for AD, MS, and, to a lesser extent, MND within the core genes of the TREM2-containing modules, implying, first, that these neurological diseases may share common pathways centred on microglial function and, second, that among the list of genes identified by this study are as-yet-unknown disease-relevant genes. This evidence concerns the gene TREM2 and Alzheimer disease.