For example, loss of function of the full-length isoform of calpain 3 results in limb girdle muscular dystrophy type 2A [13], knocking out alleles of mouse CAPN 8 and CAPN 9 results in ethanol-induced gastric injury [14], and aberrant calpain 10 activation results in type 2 diabetes [15]. Here, CAPN10 is linked to type 2 diabetes mellitus.