CHEK1 and familial pancreatic carcinoma: Previous studies demonstrated that inhibition of CHK1 by CHK1 inhibitor sensitizes pancreatic cancer to GEM by mechanisms including G2 checkpoint abrogation and homologous recombination repair inhibition [12, 45, 46]; In addition, inhibition of CHK1 by siRNA also enhances the sensitivity of GEM in pancreatic cancer cells [11].