HMOX1 and Hyperglycemia: Effective antioxidant treatment with NAC evidenced as complete prevention of hyperglycemia-induced increases in plasma and heart tissue free 15-F2t-isoprostane significantly attenuated the reduction of myocardial Brg1 protein expression, subsequently significantly enhanced myocardial p-STAT3 and HO-1, and improved cardiac relaxation in diabetic rats.