The ability of TRiC to recognize and handle both types of proposed mhtt toxic species observed in Huntington’s disease (DiFiglia et al., 1997; Arrasate and Finkbeiner, 2011; Nucifora et al., 2012), namely oligomers and fibrillar aggregates, could account for the reduced toxicity of mhtQ51 and other mhtt species when TRiC is overexpressed in cells (Behrends et al., 2006; Tam et al., 2006). Here, MARVELD2 is linked to Huntington disease.