Concerning the ANA-HEp-2 patterns indicative of specific cell domains (centromeres, nuclear envelope, and PML bodies), the centromere pattern was significantly more frequent in PBC/AID samples than in PBC (p = 0.014), BN (p < 0.001), and BN/AID samples (p = 0.021) (Table 2). This evidence concerns the gene AICDA and primary biliary cholangitis.