Examples of such include antinative DNA antibodies and systemic lupus erythematosus [20], anticitrullinated peptide antibodies or rheumatoid factor and rheumatoid arthritis [21], antithyroid peroxidase antibodies and Hashimoto thyroiditis [22], anti-insulin antibodies and type I diabetes mellitus [23], and AMAs and PBC [24]. This evidence concerns the gene INS and primary biliary cholangitis.