These included infection-regulated genes bearing IRF8 binding sites (Irf1, Ifit1, Isg15, Nlrc4, Il12p40 and Irgm1; examples of IRF8 ChIP-seq profiles are shown in Figure 3C), and genes known to play key roles in early innate immune response (Ifng, Jak3, Stat1, Il12p40). The gene discussed is ISG15; the disease is infection.