These included infection-regulated genes bearing IRF8 binding sites (Irf1, Ifit1, Isg15, Nlrc4, Il12p40 and Irgm1; examples of IRF8 ChIP-seq profiles are shown in Figure 3C), and genes known to play key roles in early innate immune response (Ifng, Jak3, Stat1, Il12p40). This evidence concerns the gene JAK3 and infection.