IRF8 and infection: This analysis (Figure 3B) showed very strong enrichment for IRF8 binding sites in the vicinity of genes increased by infection, with 74% of increased genes (92/125; p<0.0001, Fisher's Exact test) bearing one or more IRF8 binding sites within 20 kb of the TSS (Figure 3C for ChIP-seq profile examples and complete list in Table S2).