Groups of three CD11c.DOG-HBV transgenic mice were treated with DTX or saline (NaCl) every other day in combination with single administration of clodronate liposome (CLL) that is known to induce apoptosis of macrophages and DCs in vivo and in vitro [46], [47], or control liposomes (NaCl-L), yielding 4 different groups of mice (i.e. NaCl+NaCl-L, DTX+NaCl-L, CLL+NaCl, and DTX+CLL). The gene discussed is ITGAX; the disease is B-cell chronic lymphocytic leukemia.