CD8A and B-cell chronic lymphocytic leukemia: To examine the impact of pAPC-depletion on αCD40 induced functional differentiation of HBV-specific CD8+ T cells, CD11c.DOG-HBV transgenic mice that were pre-treated with DTX, CLL or DTX plus CLL, were injected with αCD40, and 1 day later, adoptively transferred with COR93-specific naïve T cells.