IL-10-deficient mice, although capable of restraining the fungal growth during the primary infection (Figure 5D) and after re-challenge (Figure S1F in Text S1), were unable to control tissue inflammation (Figure S1G in Text S1) and PMN recruitment (Figure 5E) during the infection, and this was associated with high-level production (Figure 5A) and expression (Figure 5B) of IFN-γ and IL-17A, and with high Tbet and Rorc expressions in CD4+ T cells (Figure 5C). This evidence concerns the gene RORC and infection.