Taken together, the expression of the gH/gL/UL128-131 complex on the viral envelope and the requirement for the appropriate level/type of integrin/Src/paxillin signaling, induced by the pentameric complex in infected cells, might be the evolutionary mechanism that assures the predominance of close proximity HCMV infection minimizing the recognition of virus by the immune system and at the same time allowing for efficient viral spread within the host. This evidence concerns the gene SRC and cytomegalovirus infection.