SOCS3 and infection: Tnf mRNA and protein levels were reduced in M. tuberculosis- or BCG-infected gp130F/F BMM and were partially restored in gp130F/F Il-6−/− BMM (Figure 3G and S2F, G), indicating that SOCS3 allows proper infection-induced TNF secretion in macrophages by hampering gp130/IL-6 receptor-mediated signalling.