As expected, Socs3 mRNA levels were reduced in M. tuberculosis-infected Socs3fl/fl LysM cre BMM when compared to controls (Figure 2C), and in vitro infection of BMM with M. tuberculosis stimulated STAT3 phosphorylation that was prolonged in Socs3fl/fl LysM cre BMM (Figure 2D). Here, SOCS3 is linked to infection.