Many cells were granzyme B positive (500 GrB+ cells/10 HFP figure 8D) suggesting cytotoxic potential, but very few were perforin positive (1 perforin+ cells/10 HFP figure 8E) A right lower lobe lung nodule that was suspicious for cancer was resected from an asymptomatic immunocompetent patient who was exposed to Cryptococcus on Vancouver Island, Canada. This evidence concerns the gene GZMB and cancer.