MMP3 and Parkinson disease: To our knowledge, this is the first study to demonstrate that neurotoxic effects of MMP-3 in the MPTP-treated SN are associated with the ability of MMP-3 to increase BBB damages, microglia/macrophage phagocytosis, and infiltration of T leukocytes, suggesting that MMP-3 can be novel therapeutic target for PD and other disorders associated with BBB integrity and neuroinflammation.