Given the recent findings showing activation of CXCR2 by IL-8 leads to cellular senescence in a p53-dependent manner [61], we propose that the IL-8-CXCR2-p53 axis could be the major regulatory signaling pathway to maintain the neuroendocrine cells of benign prostate and adenocarcinoma in a quiescent state. The gene discussed is CXCR2; the disease is adenocarcinoma.