This transdifferentiation model of neuroendocrine tumor cells is further supported by a recent study of secondary SCNC, showing that prostate luminal cell lines (RWPE-1 and LNCaP) have the ability to transdifferentiate into cells with a neuroendocrine-like phenotype when they were stably transfected with transcription factor N-myc or Aurora kinase A (AURKA), a serine/theronine kinase involved in cell cycle regulation [44]. Here, AURKA is linked to neuroendocrine neoplasm.