In the apoptosis resistant pancreatic ductal adenocarcinoma cell line Colo357, TRAIL treatment enhanced expression of pro-inflammatory cytokines such as interleukin-8 and monocyte chemoattractant protein 1 (MCP1) and aggravated tumour cell invasion by upregulation of urokinase-type plasminogen activator expression in vitro and in a orthotopic metastatic mouse model in vivo [73]. The gene discussed is CCL2; the disease is neoplasm.