However, in a study using colorectal carcinoma cells, tumour-cell associated DR3 was shown to bind to endothelial E-selectin, causing pro-inflammatory p38, Akt, ERK as well as NFκB activation and furthermore promoted DR3-dependent transendothelial migration of HT29 cells in a Boyden chamber assay [131,132]. The gene discussed is TNFRSF25; the disease is neoplasm.