As wild-type mice whose bone marrow was repopulated with cells from TNFR1-deficient mice exhibited a reduced development of colitis and colon cancer [43], the tumour promoting properties of TNF were at least partly attributed to its action on TNFR1-positive myeloid cells resulting in cancer-related inflammation. The gene discussed is TNFRSF1A; the disease is malignant colon neoplasm.