ELN and aortic aneurysm: This family targets numerous gene transcripts that encode ECM proteins involved in fibrotic responses, including several collagen isoforms (e.g., COL1A1, COL1A2, COL3A1), fibrillin-1, and elastin (ELN) [78], and is known to modulate gene expression during development and aging of the aorta [61] and during the progression of aortic aneurysms [61,62].