Translation of several proto-oncogenes, cytokines and many other factors, such as human 5-HT3A (5-hydroxytryptamine receptor 3A), TPO, BACE1 [β-site APP (Amyloid Precursor Protein) cleavage enzyme 1] or huntingtin protein (protein associated with Huntington's disease) are in part tightly controlled by the presence of uORFs in their 5′UTRs (117). This evidence concerns the gene HTR3A and Huntington disease.