In this regard, myelin P0 is an important auto-antigen in spontaneous and induced peripheral neuropathy [30], and development of autoimmune neuropathy in NOD mice carrying a mutant allele of Aire was associated with reduced expression of P0 in medullary thymic epithelial cells (mTECs) and loss of tolerance to P0 [34]. This evidence concerns the gene MPZ and peripheral neuropathy.