While additional studies would be needed to confirm that protection from neuritis and neuropathy in NOD-B7-2KO-Idd3/10/18 mice results from interactions between Idd3/Il2 and Idd10/Cd101, it is tempting to speculate that these interactions could improve both the number and function of Tregs and that protection by Idd3/10/18 is thus largely Treg-mediated. The gene discussed is CD101; the disease is neuropathy.