HLA-C and neuropathy: Moreover, although the immunopathology of neuropathy in NOD-B7-2KO versus NOD-H-2b-PD-1KO looked similar overall, it is possible that disease is controlled by a different set of genes in each strain, especially since the strains harbor different MHC alleles and deficiencies in distinct costimulatory pathways, which all could greatly impact the thymic selection of autoreactive T cells and their activation in the periphery.