CD80 and autoimmune thyroid disease: However, anti-B7-1 treatment did have strong effects on autoimmunity in NOD-B7-2KO-H-2h4 mice, as revealed by H&E staining of the thyroid gland showing that autoimmune thyroiditis was dramatically exacerbated in anti-B7-1-treated NOD-B7-2KO-H-2h4 mice-compared to untreated NOD-B7-2KO-H-2h4controls (Fig. 5B and C).