Indeed, 5 out of 5 anti-B7-1-treated NOD-B7-2KO-Idd3/5 and 4 out of 5 NOD-B7-2KO-Idd3/10/18 females became neuropathic by 30 weeks of age, but only 2 out of 5 and 1 out of 5, respectively, developed diabetes by 30 weeks of age. The gene discussed is CD80; the disease is diabetes mellitus.