CD80 and diabetes mellitus: Furthermore, whereas NOD-B7-2KO-Idd3/5 and NOD-B7-2KO-Idd3/10/18 were protected from neuropathy and diabetes (Fig. 3A and data not shown), anti-B7-1 treatment restored neuropathy in both congenic strains but had only a minimal effect on diabetes (Fig. 4A and B).