After adjustment for patient age, menopausal status, tumor stage, lymph node status, histological grading, multivariate analysis rendered GPER-1 as an independent, favorable prognostic factor in regard to DFS (HR, 0.569; 95% CI, 0.317-0.991; p = 0.046) (Table 2). The gene discussed is GPER1; the disease is neoplasm.