In particular, ZA2G, FCN3, CFAB, CLUS, CERU, APOE, APOA4, APOA1, ANT3, AMBP, A1AT, VTB, ACTG, ACTB and SAA molecules appeared to discriminate between low and high-risk leukemias, irrespectively of the tissue of origin; BM or PB. This evidence concerns the gene APOE and leukemia.