Among them, examples of low abundant proteins found up-regulated in BM samples derived from HR-ALL were FCN3, calmodulin-like protein 5 (CALL5) and pyruvate kinase isoenzymes M1/M2 (KRYM), whereas ubiquillin 1 (UBQL1) was found to be down-regulated. This evidence concerns the gene CALML5 and acute lymphoblastic leukemia.