New data on the CD4+ cell count trajectory during the first four years after ART initiation show that the odds of CD4+ cell recovery to 900 or more cells/μL within four years after ART initiation decreases with 10% for each incremental month of delay between the estimated date of infection and ART initiation [7] and that ART initiation during primary HIV infection can delay disease progression [6]. The gene discussed is CD4; the disease is HIV infectious disease.