Indeed, mutations in LMNA can lead to Dunnigan-type familial partial lipodystrophy (FPLD2) [5,6], but also to accelerated ageing syndromes [1-4], and to mixed overlapping phenotypes with both lipoatrophy, metabolic complications and progeroid signs [7-10]. Here, LMNA is linked to familial partial lipodystrophy, Dunnigan type.