In addition to some clinical features that distinguish lipodystrophic syndromes due to WRN as compared to LMNA mutations (as early cataracts and mesenchymal neoplasms), peculiar gynecological and obstetrical risk factors, i.e. diminished ovarian reserve and cervical incompetence, also characterize women with Werner syndrome. This evidence concerns the gene WRN and mesenchymal cell neoplasm.