In the English literature, there are at least twenty-six reported cases of colorectal carcinoma occurring in CDH1-associated HDGC kindreds; an additional eight cases of colorectal carcinoma exist in families with a history of diffuse gastric carcinoma that have tested negative for CDH1 mutations and did not meet the criteria for hereditary nonpolyposis colon cancer (HNPCC) [8-10,12,13,15,18,24-30]. The gene discussed is CDH1; the disease is colorectal carcinoma.