While TF antigen + uPA expression predicted breast diseases in both pre- and post-menopausal women with 84-92% of accuracy, interestingly and surprisingly when TF uPA + PAI-1 were combined, the predictive ability approached 97-100% allowing the near absolute prediction of both atypia or cancer disease in women requiring surgery because of a suspicious breast lesions (Figure 1). This evidence concerns the gene SERPINE1 and breast disorder.