Although these biomolecules appeared individually not perfectly accurate in predicting the presence of BC during different menopausal status, Sauter’s research team demonstrated the innovative biomarker combination in NAF[65]: 1) uPA concentration alone was more predictive of disease in premenopausal women (AUC values 0.83-0.87); 2) the range of AUC values for uPA+PAI-1 expression in all women was 0.72-0.75; 3) TF antigen alone was better at predicting BC in postmenopausal women showing range of AUC values 0.81-0.83. The gene discussed is TF; the disease is breast cancer.