SERPINE1 and cancer: In the frame of searching cancer biomarkers in breast microenvironment[26,27], a recent study published in BMC Cancer[65] reports an interesting and innovative combinatory analysis of three well-known predictive biomarkers (uPA, PAI-1, and TF) in NAF collected noninvasively (or spontaneously secreted) from healthy women, patients with breast atypia and cancer (in pre- and post-menopause), requiring surgery because of a suspicious breast lesions.