FLT3 and acute myeloid leukemia: JAK inhibitors were also found to potentiate the cytotoxicity of FLT3 inhibitors in a high-throughput screen of investigational drug combinations in a co-culture of AML and stromal cells, suggesting that JAK inhibitors may be effective in overcoming the drug resistance of AML residing in the bone marrow (Weisberg et al., 2012).