IL1A and familial pancreatic carcinoma: Sawai et al. (64) evaluated the role of IL-1 in metastatic and non-metastatic human pancreatic cancer cell lines and showed that metastatic lines demonstrate increased IL-1RI expression compared to non-metastatic cell lines, and exposure to IL-1α results in increased α6- and β1-integrin subunit expression, whereas IL-1α exposure to non-metastatic lines has no effect.