IL1RL1 and Cowden disease: In addition, a potential genetic predisposition to dysregulated IL-33/ST2 function may exist as a recent study describes the novel observation of association between the rs3939286 IL-33 polymorphism and IBD, and between the IL1RL1 rs13015714 and CD, in a well-characterized Italian cohort of adult and early onset IBD patients (155).