Mast cell degranulation, which is crucial for the activation of dendritic cells and recruitment of neutrophils and T cells to the site of infection (169, –171), is also needed for the enhanced expression and production of the tissue-derived IL-25, IL-33, and TSLP, which are required for the optimal orchestration and priming of type 2 immunity (172, 173) and are obvious, apparent events important in intestinal mucosal protection against infection. The gene discussed is IL33; the disease is infection.