IL1A and colorectal carcinoma: An imbalance in the equilibrium between IL-1 family components, dependent on prevalent isoform and receptor binding domain/accessory protein present on effector cells, maybe responsible for either driving pathogenic events, including chronic intestinal inflammation, fibrosis, and CRC, or for promoting protection by inducing epithelial repair, mucosal wound healing, and restoration of gut homeostasis (summarized in Figure 5).