SIGIRR and glomerulonephritis: In the lpr/lpr model, Tir8/Sigirr deficiency was responsible for massive lymphoproliferation, peribronchial inflammation, and mesangio-proliferative glomerulonephritis, due to B and dendritic cell hyper-activation in TLR7- and TLR9-dependent response to autoantigens and nucleosomes (115).