These include mice lacking immunosurveillance cells, such as Rag2−/− mice, which lack T cells and B cells, nude mice, CD1d−/− mice, which lack CD1d-restricted T cells, and Ja18−/− mice, lacking semi-invariant NKT cells or mice deficient in cytokines critical for anti-tumor immunity, such as IFNγ and IL-12 [reviewed in Ref. Here, CD1D is linked to neoplasm.