Transplantation assays, in which 3-MCA-induced fibrosarcoma cell lines that were derived from WT or IL-1 KO mice were injected into the same strains of mice, enabled us to define the role of IL-1 expressed by the malignant cells or the microenvironment in tumor progression (51, 77, 92, –94). This evidence concerns the gene IL1B and neoplasm.