IFNA1 and Schwartz-Jampel syndrome: Increased IFN levels, in turn, activate multiple IFN-responsive/stimulated genes (IRGs/ISGs) involved in innate and adaptive immune activities, defining a specific SjS-associated “IFN signature.” The IFN-signature of SjS patients has been reviewed recently by Dr. Rönblom and colleagues (Nordmark et al., 2012; Yao et al., 2012).