Taking into account that the DA tone in the frontal cortex is mostly determined by dopamine D1 receptors (46, –48) and that hallucinations and psychosis are especially associated with the use direct dopamine D2 agonists (49, 50), it seems reasonable to conclude that PD-psychosis is likely associated with a relative hyperdopaminergic D2 tone in the NAcc. The gene discussed is DRD1; the disease is psychotic disorder.