NR3C1 and major depressive disorder: The serotonin system is able to modulate anxiety and depression (Meaney et al., 1994; Ramboz et al., 1998; Harada et al., 2008; Brummett et al., 2012), possibly by regulating the HPA-axis through influencing glucocorticoid receptor (GR), whose activation is important in regulating the 5-HT system both in vivo and in vitro (Lanfumey et al., 2000; Erdeljan et al., 2001; Wang et al., 2009; Falkenberg and Rajeevan, 2010; Belay et al., 2011).