A loss of CREB signaling impairs adult hippocampal neurogenesis and disrupts normal hippocampal function (Jacobs et al., 2000; Urani et al., 2005), both of which have been proposed to be key pathologies of depression (Petersen et al., 2008; Lucassen et al., 2010). The gene discussed is CREB1; the disease is depressive symptom measurement.