HTR1A and major depressive disorder: Reduced post-synaptic 5-HT1A/2 receptor function has also been linked with depression with patients who had suffered major depression exhibiting global reduction in 5-HT1A and 5-HT2A receptor binding (Drevets et al., 1999, 2007; Messa et al., 2003; Moses-Kolko et al., 2008).