In relation to this observation, it is important to note that met-BDNF allele [the genotype that is shown to be associated with reduced BDNF level (14)] has been shown to be associated decreased volume (15), lower metabolic ratios of N-acetyl aspartate and glutamate (16) of the hippocampus, and as well as with reduced volume of the right inferior parietal lobule (17) – the brain regions that are implicated in the genesis of positive symptoms in schizophrenia (18). This evidence concerns the gene BDNF and schizophrenia.