In support of this finding, distinct FKBP5 genotypes have been shown to define distinct PTSD subtypes, such that while baseline cortisol levels were found to be reduced in non-risk allele carrying PTSD patients, only patients carrying the FKBP5 polymorphism risk-allele, rs9296158, show GR hypersensitivity as measured by increased dex suppression (Mehta et al., 2011). The gene discussed is FKBP5; the disease is post-traumatic stress disorder.