NR3C1 and post-traumatic stress disorder: While no epigenetic modifications to the Nr3c1 gene itself have been specifically linked to PTSD diagnosis, the mounting evidence for a role of early-life stress in mediating susceptibility for the later development of PTSD, evidence for epigenetic alterations associated with suicide, and data showing early-life stress mediation of epigenetic modifications in Nr3c1 suggest that a critical link may eventually be revealed.