Finally, in a small prospective study that included 34 patients with CHF followed for a 2-year period with monthly CRP measurements and 24-h Holter recordings, it was shown that five unexpected deaths that occurred were preceded by progressive increases in both CRP serum levels and autonomic dysfunction (low HRV indices) (Shehab et al., 2004). This evidence concerns the gene CRP and Abnormal autonomic nervous system physiology.