CXCL12 directly mediates angiogenesis through its binding to CXCR4 on endothelial cells and by recruiting endothelial progenitor cells, while indirectly it induces the secretion of pro-angiogenic factors such as VEGF, CXCL8, and CXCL1 by leukocytes, tumor cells, and endothelial cells that express CXCR4 (Verbeke et al., 2011). Here, CXCR4 is linked to neoplasm.