Studies of glioblastomas and neuroblastomas have also shown that CXCR4+ monocytes recruited to tumors promote new vascular formations within the neoplasms; the monocytes first establish themselves within perivascular areas of the tumor and then release pro-angiogenic factors such as VEGF and angiopoitins, with subsequent recruitment of bone marrow-derived endothelial and perivascular progenitors that will compose the vasculature (Jodele et al., 2005; Domanska et al., 2013). The gene discussed is CXCR4; the disease is neoplasm.