TARDBP and amyotrophic lateral sclerosis: TDP-43 inclusions are widespread in CTE cases, a small subset of CTE patients with TDP-43 inclusions in the anterior horn of the spinal cord and motor cortex develop a progressive motor neuron disease, providing further evidence that some cases of ALS may be associated with TBI (McKee et al., 2010; Stern et al., 2011).