DRD2 and Cognitive impairment: While the role of dopamine in inflammation following TBI is not well understood this new data highlighting the role of DRD2 in mediating inflammation may help to explain not only the beneficial effects of DR2 agonists on cognitive performance following experimental TBI but also the cognitive impairments witnessed following administration of certain antipsychotics such as Haloperidol which have been found to antagonize DRD2 (Wilson et al., 2003).