IGF1 and Hypertension: In contrast, our recent findings demonstrate that although liver-specific knockdown of IGF-1 (Igf1 f/f + MUP-iCre-AAV8) does not cause BBB disruption under baseline conditions, it exacerbates BBB disruption elicited by hypertension, mimicking the aging phenotype (Toth P, Csiszar A, Sonntag WE, and Ungvari Z, unpublished observation, 2012).